The novel mass humanization technology yields fully human antibodies with excellent drug-like properties in a fast and straightforward workflow
Rabbits produce robust antibody options and show a strong immune response against even challenging targets. AbCheck’s Rabbit Mass Humanization technology provides a new solution for the humanization of entire rabbit immune repertoires in one workflow reaching higher degrees of humanness compared to classic CDR grafting approaches.
Key
Highlights
Highlights
Rabbit clonal lineage analysis: Rabbit immune repertoire can be captured into four selected human scaffolds
Designed diversity in CDR1/2 representing all possible humanization including maximal germlining
CDR-H3 and CDR-L3 diversity are transferred from immunized rabbits
AbCheck has repeatedly succeeded in identifying highly
specific binders to challenging targets from our Mass
Humanization library
specific binders to challenging targets from our Mass
Humanization library
The Technology was developed in partnership with bioengineering specialists, Distributed Bio. AbCheck gained the exclusive license to the technology in 2015.
TECHNOLOGY DIAGRAM
Rabbit Mass Humanization Principle
