AbCheck discovers and optimizes human antibodies leveraging several proprietary platforms including in vitro/in vivo technologies. We use phage/yeast display libraries, mass humanization, antibody optimization and microfluidics to provide high-quality leads.
Flexibly adapting to our partners’ needs, we have proven our capabilities in multiple partnerships throughout the US and Europe.
OVERVIEW
Founded in 2009 as a spin-out of Affimed’s antibody technology discovery unit, headquartered in Plzeň, Czech Republic
Lean and agile team of experts with >20 years of expertise in antibody discovery and development
High-end technology boutique with ability to discover and develop antibodies against challenging targets and antibodies with therapeutically relevant biological functions
Projects tailored to a partner’s specific needs based on one of the industry’s most versatile technology platforms
Service provider with variety of different business models and deal structures available
Acquired by Ampersand Biomedicines, a Flagship Pioneering Company, in 2024
Our Unique Approach
Meeting our partners’ needs in therapeutic antibody discovery and development
AbCheck offers a variety of services and technologies to meet the increased demand for high-quality antibody development candidates in today’s antibody discovery world.
Flexibly adapting to your needs, we offer customized solutions, developing novel approaches beyond antibody-antigen binding affinity criteria for the discovery of therapeutic antibodies with challenging Target Product Profiles.
Antibody Discovery - Tailor-made for a partner's Target Product Profiles
It’s our partner’s choice
Immunized repertoires or in vitro repertoires (Rabbit Mass Humanization)
ELISA and SPR-based assays (e.g. ADA ELISA, serum stability, affinity studies, etc.)
Assay development
IND-enabling study data reports for regulatory authorities
Challenges we can address
Epitope-specific targeting
Broad epitope coverage
Isoform-specific antibodies
Functional antibodies
Species cross-reactivity
Special stability requirements
Picomolar affinities
Sequence diversity
Our technologies for antibody characterization
ELISA, SPR, DSF
Flow cytometry, multimode readers for functional assays
WHO WE ARE
Our Management
MANAGING DIRECTOR
Dr. Volker Lang
MANAGING DIRECTOR FINANCE AND ADMINISTRATION
Tomáš Jičínský
CHIEF TECHNOLOGY OFFICER
Dr. Oleh Petriv
VICE PRESIDENT PROJECT MANAGEMENT
Dr. Claudia Wurzenberger
VICE PRESIDENT MICROFLUIDICS-BASED DISCOVERY
Dr. Pavel Pitule
VICE PRESIDENT LIBRARY-BASED DISCOVERY
Dominik Hinz
WHO WE ARE
Our Team
We are a highly skilled and experienced team operating transparently and in agreement with the highest ethical and corporate governance standards – mutual respect, integrity and trust are our foundation.
AbCheck fosters a close, collaborative working relationship with our clients. Our experience has demonstrated that this type of close interaction is very valuable in the development of successful projects. We insist on the highest quality standard, challenge conventional thinking within our team and cultivate rigorous problem solving, resulting in best solutions and scientific innovations that help to deliver optimal results in a timely fashion.
25+
TEAM MEMBERS
50+
COFFEES PER DAY
Kateřina Křížová
Senior Scientist II Cell Biology
Dr. Yuriy Rzhepetskyy
Senior Scientist II Cell Biology
Dr. Peter Milovník
Principle Scientist Molecular Biology
Dr. Josef Čáslavský
Senior Scientist II Microfluidics
Partnering
Discover our solutions
tailored to your needs!
Careers
Do you want to join us?
OUR MANAGEMENT
Dr. Volker Lang
Managing Director
Dr. Volker Lang has more than 20 years of experience in development and commercialization of biotechnology products, encompassing basic research, R&D, business development and licensing, as well as commercial operations and management. Prior to joining AbCheck, Volker served as Chief Business Officer of Affimed Therapeutics AG (now Affimed N.V.), AbCheck’s parent company. Previous positions include Vice President for Corporate Development at Scil Technology GmbH, where he successfully partnered the company’s technology portfolio with two major pharmaceutical companies. Volker was also Vice President of Business Development & Licensing at Pieris AG, where he successfully closed key strategic partnership deals. Prior to Pieris, Volker served as Chief Operating Officer at Cosmix GmbH and Biotech Manager at Fresenius Kabi AG, where he gained considerable CMC and production experience. Volker holds a PhD in biochemistry from the University of Braunschweig, Germany.
OUR MANAGEMENT
Tomáš Jičínský
Managing Director Finance and Administration
MSc. Jičínský has many years of experience in managing companies in the Czech Republic, Germany and Austria. Before joining AbCheck, he worked as an executive at Wilden Czech, where he built a development department and production plants for the pharmaceutical and automotive industries. Mr. Jičínský is a graduate of the Czech Technical University in Prague.
OUR MANAGEMENT
Dr. Oleh Petriv
Chief Technology Officer
Dr. Oleh Petriv joined AbCheck in 2018 as Vice President New Technology Development. With his wealth of experience in R&D and technology development, he leads a team of talented researchers developing entirely new and unsurpassed methods of antibody discovery by functional criteria. Oleh received his MSc in Biochemistry from Lviv State University, Ukraine, and holds a PhD in Cell Biology from the University of Alberta in Canada. After several years of research on the role of lipids in longevity, he joined the engineering laboratory led by Dr. Carl Hansen in Vancouver. There he studied design and manufacturing of microfluidic chips, worked on high-throughput single-cell PCR and sequencing methods. Oleh is one of the co-founders of AbCellera, a company focusing on monoclonal antibody discovery based in Canada.
OUR MANAGEMENT
Dr. Claudia Wurzenberger
Vice President Project Management
Dr. Claudia Wurzenberger joined AbCheck in 2022 as VP Project Management. She brings to the company broad expertise in managing and executing projects for the discovery and development of therapeutic proteins in different disease areas, including immuno-oncology and respiratory diseases. Prior to joining AbCheck, Claudia was a Project Leader at Pieris Pharmaceuticals, leading several internal and partnered programs from early discovery into IND-enabling studies. Her experience also includes serving as Senior Scientist at Immunocore Ltd. Claudia holds a PhD in Biochemistry from ETH Zurich, and an MSc from the Technical University of Munich.
OUR MANAGEMENT
Dr. Pavel Pitule
VICE PRESIDENT MICROFLUIDICS-BASED DISCOVERY
Dr. Pavel Pitule joined AbCheck in 2018 as a scientist in the New Technology Development department and has been an integral part of the team that developed the company’s functional sorting platform, focusing on the introduction of in-droplet assays and setting up sorting system for sensitive and selective selection of functional antibodies. In 2022, he took over responsibility for AbCheck’s Discovery department, leading a team of scientists running the company’s antibody discovery projects and also coordinating the advanced technology development of AbCheck’s microfluidics technology. Pavel gained his MSc. degree in Immunology at the Faculty of Sciences, Charles University and his Ph.D. researching cancer biomarkers at the Faculty of Medicine at Charles University in Pilsen, Czech Republic. Before joining AbCheck, he led a group of scientists working in the field of liquid biopsies and solid cancer biomarkers, published over 30 scientific articles and mentored multiple doctoral and post-doctoral students.
OUR MANAGEMENT
Dominik Hinz
VICE PRESIDENT LIBRARY-BASED DISCOVERY
Dominik Hinz joined AbCheck in 2014 as Head of the Phage Display group, working as project lead on the discovery of therapeutic antibodies in numerous partnered programs. After taking over the role of Head of the Core Technologies department, in 2021 he became Head of the IND-Enabling Studies department, supporting AbCheck’s clients in developing and conducting IND-enabling studies for their therapeutic antibodies. Since the beginning of 2023 he focuses on the development of AbCheck's portfolio of library-based technologies. Dominik received his Master's degree in Biotechnology from the Technical University of Braunschweig, Germany, before joining Prof. Dr. Arne Skerra’s group at the Technical University of Munich as a research associate focussing on generation, engineering and characterization of anticalins (antibody mimetics). Prior to joining AbCheck Dominik served as R&D scientist at MorphoSys AG in partnered antibody discovery programs.
OUR TEAM
Kateřina Křížová
Senior Scientist II Cell Biology
Kateřina joined AbCheck in 2023 as an Immunology Scientist bringing many years of experience in molecular and cellular biology and immunology. She obtained her Master's degree at Palacký University Olomouc (Czech Republic) and focused on cancer biology, molecular pathology and DNA damage response at the Institute of Molecular and Translational Medicine in Olomouc (Czech Republic), Danish Cancer Society Research Center in Copenhagen (Denmark) and Institute of Molecular Genetics of the Czech Academy of Sciences in Prague (Czech Republic), where she also joined the Immunology department. After 10+ years of academic work, Kateřina moved into the industry as a Scientist in the Antibody-Drug Conjugate-development team in Research & Early Development at Sotio Biotech, focusing on next generation therapies for cancer patients, prior joining AbCheck.
OUR TEAM
Dr. Yuriy Rzhepetskyy
Senior Scientist II Cell Biology
Dr. Yuriy Rzhepetskyy joined AbCheck in 2018 as a cell biologist, strengthening the company’s cell biology and membrane protein biochemistry expertise. He has been a part of the team that developed the company’s functional sorting platform, focusing on single cell functional assay development, stable cell lines design, antibody production and characterization. Yuriy has more than ten years of experience in cell signaling research and earned his PhD in Cell Biology at the Institute of Cell Biology in Lviv, Ukraine. Prior to joining AbCheck, he held a postdoc position in the Ion Channels and Diseases Group headed by Dr. Norbert Weiss at the Institute of Organic Chemistry and Biochemistry in Prague, Czech Republic. He is the author of 16 scientific articles.
OUR TEAM
OUR TEAM
Dr. Peter Milovník
Principle Scientist Molecular Biology
Dr. Peter Milovník joined AbCheck in 2011 as Head of Protein Production. He also led antibody engineering projects, worked as project lead for phage display customer projects and was involved in the development of AbCheck’s Rabbit Mass Humanization platform. In 2018 Peter transitioned to the New Technology Development team and since 2023 he leads the Molecular Biology team. He received his Master's degree in chemistry from the Slovak Technical University in Bratislava, Slovakia, and holds a PhD in Biochemistry from the University of Bayreuth, Germany. Peter joined the lab of Prof. Andreas Plückthun at the University of Zurich, Switzerland, as a postdoc and worked on the development of protein engineering and selection techniques for in vitro evolution of GPCRs. Furthermore, he worked on directed enzyme evolution in the group of Prof. Don Hilvert at the ETH Zurich, Switzerland, and as a senior scientist in the bioanalytical assay development for Celerion Switzerland AG.
OUR TEAM
Dr. Josef Čáslavský
Senior Scientist II Microfluidics
Dr. Josef Čáslavský joined AbCheck in 2018 as a scientist in the Phage Display group, supporting the discovery of therapeutic antibodies for different customers. In 2019 he became the Head of Phage Display and successfully completed a number of antibody discovery projects using the phage display technology. In 2021 Josef joined the newly formed IND-Enabling Department as a group leader and has been involved in investigation and characterization of new therapeutic antibodies using various in vitro cell-based assays. Since 2023 he leads the Microfluidics team with main focus on the screening of immune repertoires. Josef holds a PhD in Molecular Biology from Charles University in Prague, Czech Republic.