AbCheck discovers and optimizes human antibodies leveraging
several proprietary platforms including in vitro/in vivo
technologies. We use phage/yeast display libraries, mass
humanization, antibody optimization and microfluidics to
provide high-quality leads.
Flexibly adapting to our partners’
needs, we have proven our capabilities in multiple partnerships
throughout the US and Europe.
OVERVIEW
Founded in 2009 as a spin-out of Affimed’s
antibody technology discovery unit,
headquartered in Plzeň, Czech Republic
Lean and agile team of experts with >20 years of expertise in
antibody discovery and development
High-end technology boutique with ability to discover and
develop antibodies against challenging targets and antibodies
with therapeutically relevant biological functions
Projects tailored to a partner’s specific needs based on one of
the industry's most versatile technology platforms
Service provider with variety of different business models and
deal structures available
Our Unique Approach
Meeting our partners’ needs in therapeutic antibody discovery and development
AbCheck offers a variety of services and technologies to meet the increased demand for high-quality antibody development candidates in today’s antibody discovery world.
Flexibly adapting to your needs, we offer customized solutions, developing novel approaches beyond antibody-antigen binding affinity criteria for the discovery of therapeutic antibodies with challenging Target Product Profiles.
Antibody Discovery - Tailor-made for a partner's Target Product Profiles
It’s our partner’s choice
Immunized repertoires or in vitro repertoires (Rabbit Mass
Humanization)
ELISA and SPR-based assays (e.g. ADA ELISA, serum stability, affinity studies, etc.)
Assay development
IND-enabling study data reports for regulatory authorities
Challenges we can address
Epitope-specific targeting
Broad epitope coverage
Isoform-specific antibodies
Functional antibodies
Species cross-reactivity
Special stability requirements
Picomolar affinities
Sequence diversity
Our technologies for antibody characterization
ELISA, SPR, DSF
Flow cytometry, multimode readers for functional assays
WHO WE ARE
Our Management
Managing Director
Dr. Volker Lang
Managing Director Finance and Administration
Tomáš Jičínský
Chief Technology Officer
Dr. Oleh Petriv
Vice President Project Management
Dr. Claudia Wurzenberger
Vice President Discovery
Dr. Pavel Pitule
Vice President IND Assays
Dominik Hinz
WHO WE ARE
Our Team
We are a highly skilled and experienced team operating transparently and in agreement with the highest ethical and corporate governance standards – mutual respect, integrity and trust are our foundation.
AbCheck fosters a close, collaborative working relationship with our clients. Our experience has demonstrated that this type of close interaction is very valuable in the development of successful projects. We insist on the highest quality standard, challenge conventional thinking within our team and cultivate rigorous problem solving, resulting in best solutions and scientific innovations that help to deliver optimal results in a timely fashion.
45+
Persons in 3 teams
100+
Coffees per day
Dr. Dattatrya Shetti
Scientist New Technology Development
Dr. Yuriy Rzhepetskyy
Scientist Cell Biologist
Dr. Ewa Brzozowska
Project Manager
Dr. Peter Milovník
Director Molecular Biology and Protein Engineering
Dr. Joanna Rybarczyk
Director Cell Culture
Mohammad Jamshidi
Engineer New Technology Development
Dr. Michael Tomaszowski
Director Bioassays
Dr. Josef Čáslavský
Director Antibody Characterization
Partnering
Discover our solutions
tailored to your needs!
Careers
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OUR MANAGEMENT
Dr. Volker Lang
Managing Director
Dr. Volker Lang has more than 20 years of experience in development and commercialization of biotechnology products, encompassing basic research, R&D, business development and licensing, as well as commercial operations and management. Prior to joining AbCheck, Volker served as Chief Business Officer of Affimed Therapeutics AG (now Affimed N.V.), AbCheck’s parent company. Previous positions include Vice President for Corporate Development at Scil Technology GmbH, where he successfully partnered the company’s technology portfolio with two major pharmaceutical companies. Volker was also Vice President of Business Development & Licensing at Pieris AG, where he successfully closed key strategic partnership deals. Prior to Pieris, Volker served as Chief Operating Officer at Cosmix GmbH and Biotech Manager at Fresenius Kabi AG, where he gained considerable CMC and production experience. Volker holds a PhD in biochemistry from the University of Braunschweig, Germany.
OUR MANAGEMENT
Tomáš Jičínský
Managing Director Finance and Administration
MSc. Jičínský has many years of experience in managing companies in the Czech Republic, Germany and Austria. Before joining AbCheck, he worked as an executive at Wilden Czech, where he built a development department and production plants for the pharmaceutical and automotive industries. Mr. Jičínský is a graduate of the Czech Technical University in Prague.
OUR MANAGEMENT
Dr. Oleh Petriv
Chief Technology Officer
Dr. Oleh Petriv joined AbCheck in 2018 as Vice President New Technology Development. With his wealth of experience in R&D and technology development, he leads a team of talented researchers developing entirely new and unsurpassed methods of antibody discovery by functional criteria. Oleh received his MSc in Biochemistry from Lviv State University, Ukraine, and holds a PhD in Cell Biology from the University of Alberta in Canada. After several years of research on the role of lipids in longevity, he joined the engineering laboratory led by Dr. Carl Hansen in Vancouver. There he studied design and manufacturing of microfluidic chips, worked on high-throughput single-cell PCR and sequencing methods. Oleh is one of the co-founders of AbCellera, a company focusing on monoclonal antibody discovery based in Canada.
OUR MANAGEMENT
Dr. Claudia Wurzenberger
Vice President Project Management
Dr. Claudia Wurzenberger joined AbCheck in 2022 as VP Project Management. She brings to the company broad expertise in managing and executing projects for the discovery and development of therapeutic proteins in different disease areas, including immuno-oncology and respiratory diseases. Prior to joining AbCheck, Claudia was a Project Leader at Pieris Pharmaceuticals, leading several internal and partnered programs from early discovery into IND-enabling studies. Her experience also includes serving as Senior Scientist at Immunocore Ltd. Claudia holds a PhD in Biochemistry from ETH Zurich, and an MSc from the Technical University of Munich.
OUR MANAGEMENT
Dr. Pavel Pitule
Vice President Discovery
Dr. Pavel Pitule joined AbCheck in 2018 as a scientist in the New Technology Development department and has been an integral part of the team that developed the company’s functional sorting platform, focusing on the introduction of in-droplet assays and setting up sorting system for sensitive and selective selection of functional antibodies. In 2022, he took over responsibility for AbCheck’s Discovery department, leading a team of scientists running the company’s antibody discovery projects and also coordinating the advanced technology development of AbCheck’s microfluidics technology. Pavel gained his MSc. degree in Immunology at the Faculty of Sciences, Charles University and his Ph.D. researching cancer biomarkers at the Faculty of Medicine at Charles University in Pilsen, Czech Republic. Before joining AbCheck, he led a group of scientists working in the field of liquid biopsies and solid cancer biomarkers, published over 30 scientific articles and mentored multiple doctoral and post-doctoral students.
OUR MANAGEMENT
Dominik Hinz
Vice President IND Assays
Dominik Hinz joined AbCheck in 2014 as Head of the Phage Display group, working as project lead on the discovery of therapeutic antibodies in numerous partnered programs. After taking over the role of Head of the Core Technologies department, in 2021 he became Head of the IND-Enabling Studies department, supporting AbCheck’s clients in developing and conducting IND-enabling studies for their therapeutic antibodies. Dominik received his Master's degree in Biotechnology from the Technical University of Braunschweig, Germany, before joining Prof. Dr. Arne Skerra’s group at the Technical University of Munich as a research associate focussing on generation, engineering and characterization of anticalins (antibody mimetics). Prior to joining AbCheck Dominik served as R&D scientist at MorphoSys AG in partnered antibody discovery programs.
OUR MANAGEMENT
Dr. Dattatrya Shetti
Scientist New Technology Development
Dr. Dattatrya Shetti joined AbCheck in 2022 as scientist in the New Technology Development department. Dattatrya brings to AbCheck experience in the field of cancer research, in particular in breast and lung cancer. His research has focused on targeted drug delivery systems and combination therapies as well as on circular tumor DNA and miRNA-based liquid biopsies for the diagnosis of cancer recurrence post-surgery. Dattatrya gained his Master’s degree in Biochemistry at Bangalore University, India and holds a PhD from South China University of Technology, Guangzhou, Guangdong, China.
OUR MANAGEMENT
Dr. Yuriy Rzhepetskyy
Scientist Cell Biologist
Dr. Yuriy Rzhepetskyy joined AbCheck’s New Technology Development team in 2018, strengthening the company’s cell biology and membrane protein biochemistry expertise. He has been a part of the team that developed the company’s functional sorting platform, focusing on single cell functional assay development, stable cell lines design, antibody production and final function confirmation. Yuriy has more than ten years of experience in cell signaling research and earned his PhD in Cell Biology at the Institute of Cell Biology in Lviv, Ukraine. Prior to joining AbCheck, he held a postdoc position in the Ion Channels and Diseases Group headed by Dr. Norbert Weiss at the Institute of Organic Chemistry and Biochemistry in Prague, Czech Republic. He is the author of 16 scientific articles.
OUR MANAGEMENT
Dr. Ewa Brzozowska
Project Manager
Dr. Ewa Brzozowska joined AbCheck in 2022 as a Project Manager in antibody discovery and development. Prior to joining AbCheck, Ewa was a Scientific Project Manager at Pure Biologics S.A. in Poland, where she managed two drug development projects for biologics to treat cancer. In addition, she was also Project Manager of two scientific projects granted the by National Science Center Poland. Ewa received a Master’s degree in Biotechnology from the University of Wroclaw, Poland and holds a PhD in Biology as well as a D.Sc. degree from the Institute of Immunology and Experimental Therapy Polish Academy of Science (IIET, PAS), Wroclaw, Poland. She also successfully completed postgraduate studies in Research Projects Management at Wroclaw University of Technology.
OUR MANAGEMENT
Dr. Peter Milovník
Director Molecular Biology and Protein Engineering
Dr. Peter Milovník joined AbCheck in 2011 as Head of Protein Production. He also led antibody engineering projects, worked as project lead for phage display customer projects and was involved in the development of AbCheck’s Rabbit Mass Humanization platform. In 2018 Peter transitioned to the New Technology Development team and in 2022 he became a Director in the Molecular Biology and Protein Engineering department. He received his Master's degree in chemistry from the Slovak Technical University in Bratislava, Slovakia, and holds a PhD in Biochemistry from the University of Bayreuth, Germany. Peter joined the lab of Prof. Andreas Plückthun at the University of Zurich, Switzerland, as a postdoc and worked on the development of protein engineering and selection techniques for in vitro evolution of GPCRs. Furthermore, he worked on directed enzyme evolution in the group of Prof. Don Hilvert at the ETH Zurich, Switzerland, and as a senior scientist in the bioanalytical assay development for Celerion Switzerland AG.
OUR MANAGEMENT
Dr. Joanna Rybarczyk
Director Cell Culture
Dr. Joanna Rybarczyk joined AbCheck in 2020 as an Immunology Scientist, bringing to AbCheck many years of expertise in immunology and cellular biology, vaccine development and in vivo experimental techniques. In 2022 she became a Director in the Cell Culture department. Joanna holds a Master’s degree in Biotechnology Engineering from the University of Life Sciences, Poznan, Poland and a PhD in Veterinary Sciences from the University Gent, Belgium. Prior to joining AbCheck, she was a Principal Investigator and Postdoctoral Researcher at the Laboratory for Immunology and Animal Biotechnology, Faculty of Bioscience Engineering, University Gent, Belgium.
OUR MANAGEMENT
Mohammad Jamshidi
Engineer New Technology Development
Mohammad (Behdad) Jamshidi joined AbCheck in 2022 as the New Technology Development Engineer, enhancing the company’s technology-based infrastructures and software requirements. He graduated with an MSc in Mechatronics Engineering from Azad University, the 44th Best Global University in the world for 'Engineering' based on US News, as the top graduate in Tehran, Iran. Prior to joining AbCheck, Behdad was a researcher in Iran and the Czech Republic from 2011 to 2022 and published over 50 scientific papers on emerging technologies, artificial intelligence (AI), and automation. Also, he has been selected as the World’s Top 2% Scientist in AI by Stanford University and Elsevier.
OUR MANAGEMENT
Dr. Michael Tomaszowski
Director Bioassays
Dr. Michael Tomaszowski joined AbCheck in 2011 as Head of Yeast Display and has established and expanded the company’s yeast display technology platform which has been used successfully in numerous partnered projects. He earned his PhD in Biochemistry at the Technical University of Darmstadt, Germany, in the group of Prof. Dr. Harald Kolmar. Michael has more than ten years of experience in protein and antibody engineering with the yeast display technology. In 2021 he joined the IND-Enabling Department as Group Leader and is responsible for performing a variety of in vitro PD and PK studies necessary for the IND submission of (bispecific) antibodies. Since 2022 Michael is Director of Bioassays in the IND-Enabling Department.
OUR MANAGEMENT
Dr. Josef Čáslavský
Director Antibody Characterization
Dr. Josef Caslavsky joined AbCheck in 2018 as a scientist in the Phage Display group, supporting the discovery of therapeutic antibodies for different customers. In 2019 he became the Head of Phage Display and successfully completed a number of antibody discovery projects using the phage display technology. In 2021 Josef joined the newly formed IND-Enabling Department as a group leader and has been involved in investigation and characterization of new therapeutic antibodies using various in vitro cell-based assays. Since 2022 he is the Director of Antibody Characterization in the IND-Enabling Department. Josef holds a PhD in Molecular Biology from Charles University in Prague, Czech Republic.